VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Characteristics of the energy metabolism in the kidneys in analgesic nephropathy

   
Ratnikov V.I.
PubMed Id: 1138502
Year: 1975  Volume: 21  Issue: 2  Pages: 154-158
Effect of prolonged treatment with acetyl salicylic acid (100 mg/kg) on energy metabolism was studied in dog kidney. Functional conditions of kidney were altered, which was manifested by an increase in excretion of sodium and by impairement is osmotic concentrating of urine. Studies of energy metabolism revealed uncoupling of oxidation and phosphorylation and also some decrease in the activity of glycolytic processes. The observed alterations in bioenergetics of kidney tissue are considered as important factors in development of analgetic nephropathy.
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Reference:

Ratnikov V.I. (1975) Voprosy meditsinskoi khimii, 21(2), 154-158.
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