VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Haptoglobin and ceruloplasmin in systemic scleroderma

   
Volkova Z.I., Kainova A.S., Balabanova R.M.
PubMed Id: 888393
Year: 1977  Volume: 23  Issue: 3  Pages: 294-297
Content of haptoglobin and ceruloplasmin was estimated in blood serum of 23 patients with sclerodermia systematica. A statistically distinct decrease in ceruloplasmin concentration was observed in blood of the patients, whereas content of haptoglobin was markedly increased; this phenomenon reflects a level of the pathological process activity. The proteins are synthesized in various zones of liver lobes: haptoglobin--in the central zone, ceruloplasmin - in the peripheral one. Decrease in content of ceruloplasmin in blood of patients with sclerodermia systematica was due to impairment of hepatocytes, localized in peripheral parts of liver lobes.
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Volkova, Z. I., Kainova, A. S., Balabanova, R. M. (1977). Haptoglobin and ceruloplasmin in systemic scleroderma. Voprosy meditsinskoi khimii, 23(3), 294-297.
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