VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

Inhibitory effect of deoxyadenylyl-(3'-5')-deoxyguanosine on the RNA-polymerase activity of influenza virus A

   
Pravdina N.F., Veselovskaia T.V., Smirnov V.D., Galegov G.A.
PubMed Id: 4090358
Year: 1985  Volume: 31  Issue: 5  Pages: 123-125
Deoxyadenylylguanosine (dAdG, 0.2-0.4 mM), affecting the RNA polymerase activity, caused inhibition of transcription of the influenza A virus in presence of precursor AdG by 50-60% and a 80-85% inhibition in absence of the precursor. The inhibitor exhibited its effect independently on the time of addition into an incubation mixture. Addition of 0.5 mM inhibitor into a cultural medium inhibited reproduction of the influenza A virus in a culture of chicken embryonal fibroblasts.
Download PDF:
Reference:

Pravdina N.F., Veselovskaia T.V., Smirnov V.D., Galegov G.A. (1985) Voprosy meditsinskoi khimii, 31(5), 123-125.
References
 2002 (vol 48)
 2001 (vol 47)
 2000 (vol 46)
 1999 (vol 45)
 1998 (vol 44)
 1997 (vol 43)
 1996 (vol 42)
 1995 (vol 41)
 1994 (vol 40)
 1993 (vol 39)
 1992 (vol 38)
 1991 (vol 37)
 1990 (vol 36)
 1989 (vol 35)
 1988 (vol 34)
 1987 (vol 33)
 1986 (vol 32)
 1985 (vol 31)
        

© Institute of Biomedical Chemistry, Moscow, Russia