Some patterns of the antioxidant system were altered in rat blood and tissues after treatment with noise of 90 dB. Phase alterations were found in content of SH- and SS-groups, in ascorbate-dependent redox balance as well as in activity of glutathione reductase, glucose-6-phosphate- and lactate dehydrogenases. These data suggest that the antioxidant system is of importance in the adaptation reactions. Administration of antioxidant drugs (unitol, ascorbic acid and tocopherol) normalized the antioxidant drugs (unitol, ascorbic acid and tocopherol) normalized the antioxidant system patterns studied. These drugs could be used to enhance the nonspecific body resistance to noise stress.