VOPROSY MEDITSINSKOI KHIMII (ISSN 0042-8809)

The effect of rolitetracycline on the level of nonesterified fatty acids, phospholipids, and triacylglycerols in ischemic damage to the myocardium

   
Sedlakova A., Kollar J., Ondreikova M., Rynikova A., Rozdobud'kova V., Pitkova S.
PubMed Id: 8279129
Year: 1993  Volume: 39  Issue: 5  Pages: 10-13
Myocardial ischemia developed in rabbits after ligation of coronary artery within 60 min. Single dose of rolytetracycline 40 mg/kg was administered intravenously before or after ligation. Alterations in content of unesterified fatty acids and phospholipids were studied in blood serum as well as of unesterified fatty acids, phospholipids and triacyl glycerols--in the myocardium. After ligation of coronary artery content of unesterified fatty acids and phospholipids was increased 2-fold in blood serum as compared with control values, while in the ischemic myocardium these substances were increased more than 2-fold and triacyl glycerol--about 7-fold. Administration of rolytetracycline before ligation of the artery led to a decrease in content of unesterified fatty acids and phospholipids in blood serum down to control values; the ligation-induced high content of triacyl glycerols and phospholipids in the myocardium was also decreased, while alterations in unesterified fatty acids content were not similar. Rolytetracycline administered after the artery ligation caused a decrease in content of unesterified fatty acids but triacyl glycerols were markedly increased. The antibiotic did not affect the lipid content in nonischemized tissues of myocardium.
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Sedlakova A., Kollar J., Ondreikova M., Rynikova A., Rozdobud'kova V., Pitkova S. (1993) Voprosy meditsinskoi khimii, 39(5), 10-13.
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