Monoclonal antibodies in diagnostics of high-grade gliomas

   
Baklaushev V.P.1 , Pavlov K.A.1, Chekhonin V.P.1

1. Laboratory of Immunochemistry Serbsky National Centre for Social and Forensic Psychiatry
Section: Review
UDK: 616.097;576.8.077      PubMed Id: 19507338
Year: 2009  Volume: 55  Issue: 2  Pages: 140-154
The review is focused on the modern methods of radioimmune diagnostics of high-grade gliomas with monoclonal antibodies and other approaches of radioimmunolocalisation with pretargeted bispecific antibodies. High-grade tumor-related proteins were analysed as potential targets for radiolabeled antibodies. Recent experimental and clinical data and the most promising immunochemical approaches for diagnostic and targeted therapy of gliomas with tumor-specific antibodies are discussed.
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Baklaushev V.P., Pavlov K.A., Chekhonin V.P. (2009) Biomeditsinskaya khimiya, 55(2), 140-154.
This paper is also available as the English translation:10.1134/S1990750809020012
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