Neuromediator systems in some brain regions of rats subjected to morphine intoxication

   
Lelevich S.V.1 , Novokshonov A.A.2

1. Grodno State Medical University
2. Institute of Biochemistry, Byelorussian Academy of Sciences
Section: Experimental/Clinical Study
DOI: 10.18097/pbmc20105605562      PubMed Id: 21254626
Year: 2010  Volume: 56  Issue: 5  Pages: 562-569
The content of neuromediators and its metabolites in the cortex of cerebral hemispheres, in thalamus and brain stem was studied under chronic morphine intoxication (7-21 days). The morphine intake during 7-14 days was accompanied by changes of catecholamine system functioning, which was the most pronounced in the thalamus and the brain stem. These changes included increased secretion of dophamine and noradrenaline, their decrease in the brain tissue, and the increased content of their metabolites. The changes of serotonin and GABA content were less pronounced and included a decrease of serotonin level and the increase of the GABA content in different periods of narcotization.
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Keywords: morphin, brain, dophamin, noradrenalin, serotonin, GABA
Citation:

Lelevich, S. V., Novokshonov, A. A. (2010). Neuromediator systems in some brain regions of rats subjected to morphine intoxication. Biomeditsinskaya khimiya, 56(5), 562-569.
This paper is also available as the English translation: 10.1134/S1990750811020065
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