Studies of mutagenic activity of positively charged alkyl glycerolipids in ames test

   
Romanova S.G.1 , Belickii G.A.2, Hitrovo I.A.2, Serebrennikova G.A.1, Shtil A.A.2

1. Department of Chemical Technology of Biologically Active Compounds, M.V. Lomonosov Moscow Academy of Fine Chemical Technology
2. Blokhin Oncological Research Center, Russian Academy of Medical Sciences
Section: Experimental/Clinical Study
DOI: 10.18097/pbmc20115704429      PubMed Id: 22066268
Year: 2011  Volume: 57  Issue: 4  Pages: 429-434
Mutagenic activity of non-phosphorous cationic alkyl glycerolipid rac-N-{ 4-[(2-Methoxy- 3-octadecyloxy)propyl]oxycarbonylbutyl}-N,N-dimethyl-N-(2-hydroxyethyl) ammonium iodide was evaluated. According performed Ames assay results indicated on non-mutagenic properties tested compound. Resulting data open the possibility to carry out biological study in vivo for class of ether cationic glycerolipids and further applications as a potential agent of anticancer therapy.
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Keywords: cationic glycerolipids, ester lipids, edelfosine, antitumor activity, mutagens activity, apoptosis
Citation:

Romanova, S. G., Belickii, G. A., Hitrovo, I. A., Serebrennikova, G. A., Shtil, A. A. (2011). Studies of mutagenic activity of positively charged alkyl glycerolipids in ames test. Biomeditsinskaya khimiya, 57(4), 429-434.
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