Carbohydrates metabolism disturbances when simulating prenatal alcohol intoxication

Kurch N.M.1 , Vysokogorsky V.E.1

1. Omsk State Medical Academy of Public Health and Social Development Ministry of Russian Federation
Section: Experimental/Clinical Study
DOI: 10.18097/pbmc20135905523      PubMed Id: 24479342
Year: 2013  Volume: 59  Issue: 5  Pages: 523-529
The influence of prenatal alcohol intoxication on carbohydrate metabolism markers has been investigated at different terms of postnatal offspring development (15, 30 and 60 days). Plasma glucose decreased as compared with the same in control group was detected. In the liver homogenates an increase of phosphorylase activity and a decrease of glucose-6-phosphatase, aldolase and glucose-6-phosphate dehydrogenase activities were found. These changes were accompanied by the incease in the lactate/pyruvate index attributed to increased lactate content in the liver tissue. The obtained data indicate essential disturbances of carbohydrate metabolism markers in prenatal alcoholized offspring, which include stable hypoglycemia, suppression of glycolytic and pentosephosphate pathways of glucose metabolism and lactate accumulation in the liver.
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Keywords: Prenatal alcohol intoxication, carbohydrate metabolism, hypoglycemia, glycogenolysis, pentose-phosphate way, glycolysis

Kurch, N. M., Vysokogorsky, V. E. (2013). Carbohydrates metabolism disturbances when simulating prenatal alcohol intoxication. Biomeditsinskaya khimiya, 59(5), 523-529.
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