Data on the chemical composition of triterpenic and steroid compounds, isolated from the chaga mushroom grown in natural environment or in a synthetic culture have been summarized. Special attention has been paid to the biological activity of chaga mushroom extracts and these particular compounds against various cancer cell lines in vitro and in vivo. This analysis has demonstrated some common features in inhibition of growth of various cell lines by chaga mushroom components. In this context, the most active are triterpene compounds containing OH group at C-22 and a side chain unsaturated bond.
Download PDF:
Keywords: chaga mushroom, triterpenes, steroids, biological activity, in vivo, in vitro
Citation:
Nikitina S.A., Khabibrakhmanova V.R., Sysoeva M.A. (2016) Composition and biological activity of triterpenes and steroids from Inonotus obliquus (chaga). Biomeditsinskaya khimiya, 62(4), 369-375.
Nikitina S.A. et al. Composition and biological activity of triterpenes and steroids from Inonotus obliquus (chaga) // Biomeditsinskaya khimiya. - 2016. - V. 62. -N 4. - P. 369-375.
Nikitina S.A. et al., "Composition and biological activity of triterpenes and steroids from Inonotus obliquus (chaga)." Biomeditsinskaya khimiya 62.4 (2016): 369-375.
Nikitina, S. A., Khabibrakhmanova, V. R., Sysoeva, M. A. (2016). Composition and biological activity of triterpenes and steroids from Inonotus obliquus (chaga). Biomeditsinskaya khimiya, 62(4), 369-375.
Lovyagina E.V., Shivrina A.N. (1965) v kn.: Kormovye belki i fiziologicheski aktivnye veshchestva dlya zhivotnovodstva, M.-L., s. 59–64. Scholar google search
Mazurkiewicz W., Rydel K., Pogocki D., Lemieszek M.K., Langner E., Rzeski W. (2010)Acta Poloniae Pharmaceutica - Drug Research, 67(4), 397-406. Scholar google search
Mazurkiewicz W. (2006) Acta Poloniae Pharmaceutica, 63, 497-501. Scholar google search
Zheng W., Zhang M., Zhao Y., Miao K., Pan S., Caoa F., Daic Y. (2011) Phytochem. Anal., 22, 95-102. CrossRef Scholar google search
Gao Y., Xu H., Lu Z., Xu Z. (2009) Chin. J. Chromatogr., 29, 745-749. Scholar google search
Shin Y., Tamai Y., Terazawa M. (2001) Euras. J. Forest Res., 2, 27-30. Scholar google search
Nizkovskaya O.P., Milova N.M., Shivrina A.N., Lovyagina E.V., Platonova E.G. (1959) Trudy instituta mikrobiologii AN SSSR, 6, 277-285. Scholar google search
Shashkina M.Ya., Shashkin P.N., Sergeev A.V., Goryajnova L.K. (2008) Chaga, chagovit, chagalyuks v lechebnoj i profilakticheskoj praktike, Kholding EDAS, M., 64 s. Scholar google search
Sysoeva M.A. (2013) Vysokodispersnye kolloidnye sistemy i melaniny chagi, Kazan', 226 s. Scholar google search
