Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effect of various combinations of antibacterial drugs on enzyme activity in guinea pig tissues

   
Kruchakova F.A., Izabolinskaia R.M., Polner R.A.
PubMed Id: 5317614
Year: 1971 vol: 17  issue:4  pages: 356-360
Abstract: Experiments were run on three groups of healthy guinea pigs. One group was given ethionamide, kanamycin and PASA another was given ethionamide, kanamycin and pyrazinamide while the third served as a control. These studies permitted to establish that the above drugs affect the activity of enzymes involved in the metabolism of carbohydrates and nucleic acids. Activity of glucose-6-phosphatase and aldolase significantly decreased in liver, brain and lung tissue. At the same time, activity of deoxyribonuclease and ribonuclease in the tissues concerned sharply increased. Changes in activity of phosphohexose isomerase, lactate dehydrogenase and aminotransferases in these tissues was statistically insignificant.
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Reference: Kruchakova F.A., Izabolinskaia R.M., Polner R.A., Effect of various combinations of antibacterial drugs on enzyme activity in guinea pig tissues, Voprosy meditsinskoi khimii, 1971, vol: 17(4), 356-360.
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