Voprosy meditsinskoi khimii (ISSN 0042-8809)

Noncoagulative catabolism of fibrinogen

Davydov V.S., Zubairov D.M., Maianskaia N.N., Iunosov R.V.
PubMed Id: 1091092
Year: 1975 vol: 21  issue:1  pages: 35-40
Abstract: In catabolism of fibrinogen a function of Cupfer endothelial cells isolated from dog and rabbit liver tissue, was studied. In lysosomal-mitochondrial fraction of Cupfer cells and activator of plasminogen was found. Proteolytic and esterase (hydrolysis of benzoyll-agronine methyl ester) activities were the most typical for lysosomal-mitochondril and supernatant fractions of Cupfer cells. The enzymatic hydrolysis of fibrinogen was not observed in cytoplasmic matrix. The data obtained suggest that under the physiological conditions non-coagulational catabolism of fibrinogen occurred mainly intracellularly.
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Reference: Davydov V.S., Zubairov D.M., Maianskaia N.N., Iunosov R.V., Noncoagulative catabolism of fibrinogen, Voprosy meditsinskoi khimii, 1975, vol: 21(1), 35-40.