Voprosy meditsinskoi khimii (ISSN 0042-8809)

Oxidation of succinic acid in the liver mitochondria in chronic enterocolitis and after resection of the small intestine

   
Khadzhiev K.Kh., Chirko I.G.
PubMed Id: 1119112
Year: 1975 vol: 21  issue:1  pages: 62-65
Abstract: In liver tissue of dogs with experimental chronic enterocolitis rate of phosphorylation and P/O coefficient were decreased, when succinic acid was used as a substrate of oxidation. Within 10-40 days after resection of 1/2 part of small intestine in rats oxidation of succinate was increased with simultaneous decrease in P/O coefficient in liver tissue. In mitochondria of liver tissue on 20th and 30th day after the operation the succinate dehydrogenase activity was increased. In remote period after resection of small intestine (90 days) rates of succinate oxidation and P/3 coefficient approached the normal values, found in liver tissue.
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Reference: Khadzhiev K.Kh., Chirko I.G., Oxidation of succinic acid in the liver mitochondria in chronic enterocolitis and after resection of the small intestine, Voprosy meditsinskoi khimii, 1975, vol: 21(1), 62-65.
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