Voprosy meditsinskoi khimii (ISSN 0042-8809)

Change in the glycolytic and glucose-6-phosphate dehydrogenase activity in experimental cirrhosis of the liver

   
Potekhinskaia T.V., Tsyrlov I.B., Liakhovich V.V., Iakobson G.S.
PubMed Id: 164085
Year: 1975 vol: 21  issue:1  pages: 70-73
Abstract: Development of cirrhosis of liver tissue did not influence the intensity of glycolysis, with glucose as a substrate, in supernatant fraction of liver homogenate in chronic intoxication with CCL4. In preparations of cirrhotic liver, as compared with liver from the intact animals, more distinct activation of glycolysis was caused by addition of ATP and NAD at the stage of 3-week intoxication and also by addition of hexokinase, glyceraldehydephosphate dehydrogenase and lactate dehydrogenase at the stage of distinct cirrhosis of liver (6 weeks of CCL4 intoxication). Km values for glucose-6-phosphate dehydrogenase increased over all the periods of intoxication.
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Reference: Potekhinskaia T.V., Tsyrlov I.B., Liakhovich V.V., Iakobson G.S., Change in the glycolytic and glucose-6-phosphate dehydrogenase activity in experimental cirrhosis of the liver, Voprosy meditsinskoi khimii, 1975, vol: 21(1), 70-73.
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