Voprosy meditsinskoi khimii (ISSN 0042-8809)

Serotonin and monoamine oxidase activity in the dynamics of experimental neuroallergy

   
Khoruzhaia T.A.
PubMed Id: 1119120
Year: 1975 vol: 21  issue:1  pages: 98-103
Abstract: A phasic type of alterations was observed in concentration of serotonin and in the monoamine oxidase activity (MAO, EC 1.4.3.4) in blood, spinal fluid and other tissues of dog in experimental allergic encephalomyelitis. In the preparalytic period a decrease in content of the amine was observed in the brain part studied and in blood; in spinal fluid content of the amine was increased. During the period of clinical manifestations of encephalomylitis reduction in content of serotonin was found in hypothalamus and brain cortex; in white substance, spinal fluid and blood content of the amine was decreased. Content of serotonin was decreased in blood and other tissues of animals without clinical manifestations of experimental allergic encephalomyelitis. In dynamics of the process the MAO activity was increased only in cortex of big hemispheres; distinct alterations were not shown in hypothalamus and white substance. The MAO activity was increased only in white substance of animals without clinical manifestations of experimental allergic encephalomyelitis. A possible mechanism and function of alterations in content of monoamines in brain under experimental allergic encephalomyelitis are discussed.
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Reference: Khoruzhaia T.A., Serotonin and monoamine oxidase activity in the dynamics of experimental neuroallergy, Voprosy meditsinskoi khimii, 1975, vol: 21(1), 98-103.
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