Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effect of an inhibitor of a trypsin-like enzyme on the degradation of liver proteins under normal conditions and in thermic burns

   
Zayets T.L., Kotkina T.I.
PubMed Id: 1216758
Year: 1975 vol: 21  issue:4  pages: 380-382
Abstract: Degradation of proteins in liver tissue slices, estimated by liberation of 14C-glycine, was increased in the animals which were subjected to burns. The cathepsin D activity was found to be simultaneously increased in extracts of the liver tissue. In burnt rats, administered with an inhibitor of trypsin-like enzymes (contrical) during 8 days after the burning, the rates of protein degradation and the values of cathepsin D activity approached those characteristics for the normal animals. Addition of the inhibitor into incubation samples did not effect degradation of liver tissue proteins and the enzymatic activity.
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Reference: Zayets T.L., Kotkina T.I., Effect of an inhibitor of a trypsin-like enzyme on the degradation of liver proteins under normal conditions and in thermic burns, Voprosy meditsinskoi khimii, 1975, vol: 21(4), 380-382.
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