Voprosy meditsinskoi khimii (ISSN 0042-8809)

Activity of Mg 2+, Na+ and K+ stimulated ATPase in erythrocytes of patients with phobic neurosis and the effect of lithium carbonate on the enzymatic activity

   
Sechenov S.I.
PubMed Id: 129954
Year: 1975 vol: 21  issue:4  pages: 382-385
Abstract: Activity of ATPases was studied in erythrocytes of patients with phobia neurosis of the 11 degree and in erythrocytes of mentally healthy patients. The total Mg2+, Na+, K+-dependent ATPase activity of patients with the neurosis was unaltered in blood. But the Mg2+-ATPase activity was increased and the Na+, K+-ATPase activity was decreased in the patients as compared with the control group. Addition of lithium carbonate into incubation mixtures exhibited different effect on the Na+, K+-stimulated ATPase depending upon the initial activity of the enzyme. In blood of patients with low initial values of the enzymatic activity it was increased. But the Na+, K+-ATPase activity was decreased by lithium carbonate in those cases when the initial enzymatic activity was high. Quantitatively the effect of lithium on the enzymatic activity was similar in the both groups of neurotic patients studied (although the direction of changes was oposite).
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Reference: Sechenov S.I., Activity of Mg 2+, Na+ and K+ stimulated ATPase in erythrocytes of patients with phobic neurosis and the effect of lithium carbonate on the enzymatic activity, Voprosy meditsinskoi khimii, 1975, vol: 21(4), 382-385.
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