Voprosy meditsinskoi khimii (ISSN 0042-8809)

The function of shuttle systems of liver extramitochondrial hydrogen transport in experimental atherosclerosis

   
Gil'miyairova F.N., Radomskaya V.M.
PubMed Id: 3020
Year: 1975 vol: 21  issue:5  pages: 476-480
Abstract: An enzymatic activity of shuttle systems for reduction equivalents transport (malate-aspartate, glycerophosphate, lactate, glutamate and beta-hydroxybutyrate dehydrogenase) was studied spectrophotometrically in liver tissue of intact rabbits and animals with experimental atherosclerosis. Content of malate, oxaloacetate, glutamate, alpha-ketoglutarate, alpha-glycerophosphate, dihydroacetone phosphate, lactate, pyruvate, beta-hydroxybutyrate and acetoacetate were studied. In experimental atherosclerosis coordinated functioning of the enzymes, which participate in the utilization of the cytoplasmic NAD-H2 and the alteration in the ratio of reduced and oxidized metabolites in the systems, were found to be impaired.
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Reference: Gil'miyairova F.N., Radomskaya V.M., The function of shuttle systems of liver extramitochondrial hydrogen transport in experimental atherosclerosis, Voprosy meditsinskoi khimii, 1975, vol: 21(5), 476-480.
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