Voprosy meditsinskoi khimii (ISSN 0042-8809)

The effect of lipids from typhoid endotoxin on the activity of some liver enzymes

   
Muzhichenko A.V.
PubMed Id: 3021
Year: 1975 vol: 21  issue:5  pages: 494-497
Abstract: Sublethal doses of typhoid endotoxin distinctly increased the activities of glutamate dehydrogenase and histidine ammonium lyase in liver tissue of mice within 3 hrs and the tyrosine transaminase activity within 6 hrs after a single intraperitoneal administration. Within 24 hrs normalzation of these enzyme activities and a decrease in the urocaninase activity were observed in liver tissue. Lipid A, obtained from the endotoxin, activated glutamate dehydrogenase and histidine ammonium lyase, inhibited urocaninase but did not affect the tyrosine transaminase activity. Lipid B, isolated by a non-hydrolytic method, showed even wore distinct capacity to activate glutamate dehydrogenase and histidine ammonium lyase, but did not alter the activities of tyrosine transaminase and urocaninase in liver tissue.
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Reference: Muzhichenko A.V., The effect of lipids from typhoid endotoxin on the activity of some liver enzymes, Voprosy meditsinskoi khimii, 1975, vol: 21(5), 494-497.
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