Voprosy meditsinskoi khimii (ISSN 0042-8809)

Mechanism of changes in oxidative phosphorylation in the kidney in nephropathy caused by post-transfusion complications

   
Shepotinovsky V.I., Mikashinovich Z.I.
PubMed Id: 175570
Year: 1975 vol: 21  issue:6  pages: 577-581
Abstract: A decrease in cytochrome c oxidase activity was observed in kidney tissue within 40 min after the transfusion of incompatible blood; at the same time, the succinate dehydrogenase activity was not altered. Opposite ratios (as compared with normal kidney) of the enzymatic activities were found within 24 hrs after a heterohemotransfusion. An addition of 5 M succinate to the kidney homogenate in vitro or administration of the substance at a dose of 8 mg per 100 g of body weight in vivo caused an activation of free oxidation and a decrease of phosphorylation. The addition of 50 M succinate, combined with hexokinase and NADH2, into the homogenate distinctly increased both the rate of tissue respiration and the coupled phosphorylation.
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Reference: Shepotinovsky V.I., Mikashinovich Z.I., Mechanism of changes in oxidative phosphorylation in the kidney in nephropathy caused by post-transfusion complications, Voprosy meditsinskoi khimii, 1975, vol: 21(6), 577-581.
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