Voprosy meditsinskoi khimii (ISSN 0042-8809)

Subcellular localization, isoenzyme spectrum and properties of hexokinase from sarcoma M-1

   
Alexakhina N.B., Goncharova N.Yu.
PubMed Id: 1216775
Year: 1975 vol: 21  issue:6  pages: 609-613
Abstract: In sarcoma M-I the hexokinase activity was found to exceed three-fold the enzyme activity in muscular tissue. In the muscles and tumor intracellular distribution of hexokinase was essentially the same; the main part of the enzyme was localized in hyaloplasma. The mitochondrial hexokinase from sarcoma M-I was solubilized by considerably higher concentrations of KC1 (0.5 M), as compared with those required for the solubilization of the enzyme from muscular tissue (0.05 M). Studies of electrophoretic, kinetic properties and thermolability of the tumor enzyme demonstrated that only two hexokinase isoenzymes were found in sarcoma M-I hyaloplasm as compared with muscular tissue where isoenzymes I, II and IV were observed.
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Reference: Alexakhina N.B., Goncharova N.Yu., Subcellular localization, isoenzyme spectrum and properties of hexokinase from sarcoma M-1, Voprosy meditsinskoi khimii, 1975, vol: 21(6), 609-613.
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