Voprosy meditsinskoi khimii (ISSN 0042-8809)

Isolation and properties of 2 kallikreins from human saliva

   
Vovchuk S.V., Barabash R.D., Levitsky A.P.
PubMed Id: 3025
Year: 1975 vol: 21  issue:6  pages: 622-625
Abstract: Two kallikreins (K-I and K-II) were purified from mixed, parotid and submandibular human saliva. The kallikreins were separated by chromatography on CM-cellulose. The pH optima of activity were at pH 9.3 and pH 9.6-9.8; Km for BAEE was 1.10-3M and 4.10-3M, respectively. The esterase activity of K-I and K-II was inhibited by trasylol-like inhibitors, while the plant and synthetic inhibitors of trypsin were uneffective. In dog, rabbit and rat the hypotensive effect of K-II and its action upon the permeability of rabbit skin was 4-5 fold higher than the effects of K-I. Ki and K-II did not alter the arterial blood pressure in guinea pig.
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Reference: Vovchuk S.V., Barabash R.D., Levitsky A.P., Isolation and properties of 2 kallikreins from human saliva, Voprosy meditsinskoi khimii, 1975, vol: 21(6), 622-625.
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