Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effect of carboxycathepsin on biological activity of bradykinin

Egorova T.P., Eliseeva I.E.
PubMed Id: 193287
Year: 1976 vol: 22  issue:1  pages: 119-122
Abstract: An effect of carboxycathepsin (peptidyl-dipeptidase EC from bovine kidney on bradikinine was studied. The bradikinine activity was determined by monitoring the rat uterine horn retraction. Carboxycathepsin caused rapid inactivation of bradikinine (440-500 mcg of bradikinine/mg/min). The rate of bradikinine inactivation depended on the incubation time, content of the enzyme and substrate in the samples. In presence of EDTA carboxycathepsin did not inactivate bradikinine.
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Reference: Egorova T.P., Eliseeva I.E., Effect of carboxycathepsin on biological activity of bradykinin, Voprosy meditsinskoi khimii, 1976, vol: 22(1), 119-122.