Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effect of amizil on phospholipid metabolism in different parts of the brain

   
Gerasimova I.A., Flerov M.A.
PubMed Id: 193289
Year: 1976 vol: 22  issue:1  pages: 72-75
Abstract: Effect of central M-cholinolytic amizyle on incorporation of 2-14C-acetate in phospholipids of big hemispheres, cortex of big hemispheres, cerebellum and stem was studied. In administration of amizyle the most distinct alterations were observed in cortex of big hemispheres and cerebellum. In cortex of big hemispheres the specific activity of inosine monophosphate and phosphatidyl choline were increased by 77% and 97%, respectively; the specific activity of phosphatidic acid was decreased by 63%. In cerebellum the specific activity of inosine monophosphate was decreased by 52.5% and of phosphatidyl serine was increased by 95%. Distinct alterations were not observed in the intensity of incorporation of labelled precursor into phospholipids of stem. In big hemispheres the specific activity of the only inosine monophosphate was decreased by 57%.
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Reference: Gerasimova I.A., Flerov M.A., Effect of amizil on phospholipid metabolism in different parts of the brain, Voprosy meditsinskoi khimii, 1976, vol: 22(1), 72-75.
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