Voprosy meditsinskoi khimii (ISSN 0042-8809)

Lactate dehydrogenase isoenzymatic activity in different parts of the brain and in the blood serum of rats from different lines during a convulsive seizure caused by the action of a sound stimulus

   
Amadian M.G.
PubMed Id: 1025881
Year: 1976 vol: 22  issue:2  pages: 161-166
Abstract: Total lactate dehydrogenase activity and relative activities of LDH-1 and LDH-2 isozymes were found to be distinctly elevated in the cortex of cerebral hemispheres (locomotory region) and in medulla oblongata of audiogenic rats KM strain. The increase in the total LDH activity was also observed in blood serum of rats KM strain. The increase in the total LDH activity and in LDH-4 and LDH-5 activities in the brain regions studied was shown in epileptoid convulsions of audiogenic origin. These alterations demonstrated the compensatory activation of glycolysis in the brain tissue.
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Reference: Amadian M.G., Lactate dehydrogenase isoenzymatic activity in different parts of the brain and in the blood serum of rats from different lines during a convulsive seizure caused by the action of a sound stimulus, Voprosy meditsinskoi khimii, 1976, vol: 22(2), 161-166.
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