Voprosy meditsinskoi khimii (ISSN 0042-8809)

Study of the active calcium transport mechanisms in uterine smooth muscle

   
Kurskiĭ M.D., Fedorov A.N., Iakovenko A.P.
PubMed Id: 140526
Year: 1976 vol: 22  issue:2  pages: 223-227
Abstract: Calcium ions were shown to be actively accumulated in mitochondrial and microsomal fractions of uterine smooth muscle of rabbit and cattle. In presence of magnesium ions Ca2+ (10-6-10-4 M) activate microsomal ATPase from cattle uterus. The rate of formation and dissociation of the intermediate phosphorylated substance of Mg2+, Ca2+-ATPase was found to be lower in microsomes of smooth muscles than in sarcoplasmic reticulum of sceletal muscles. Serotonine (concentration 10-6 M) increased the dissociation of the intermediate phosphorylated substance from microsomes of uterine smooth muscle and decreased their capacity to bind Ca2+. At the same concentration serotonine inhibited the ATP-dependent accumulation of 45Ca by microsomes of uterine smooth muscle.
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Reference: Kurskiĭ M.D., Fedorov A.N., Iakovenko A.P., Study of the active calcium transport mechanisms in uterine smooth muscle, Voprosy meditsinskoi khimii, 1976, vol: 22(2), 223-227.
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