Voprosy meditsinskoi khimii (ISSN 0042-8809)

Purification and properties of the serotonin-stimulated adenylate deaminase from the mitochondrial fraction of rat liver

   
Gridneva L.I., Suvorov N.N., Gorkin V.Z.
PubMed Id: 16394
Year: 1976 vol: 22  issue:2  pages: 245-254
Abstract: A method is described for partial purification of structurally bound adenilate desaminase from rat liver tissue mitochondria; the enzyme was stimulated by parenteral administration of serotonine. The enzymatic preparations obtained desaminated AMP, 2',3'-AMP and adenosine, but they did not effect on ATP, 2',3'-cycloAMP or 3',5'-cycloAMP. The maximal rate of desaminating of these substances by AMP-desaminase, stimulated with serotonine, exceeded approximately 1.4-fold the same values, which were obtained for the enzymatic preparations from liver tissue mitochondria of rats, administered with physiological solution. Mitochondrial serotomine-stimulated adenilate desaminase was differentiated from the other soluble adenilate desaminases by some properties; the enzyme was likely to participate also in the regulation of nucleotides balance in the organism.
Download PDF:
Reference: Gridneva L.I., Suvorov N.N., Gorkin V.Z., Purification and properties of the serotonin-stimulated adenylate deaminase from the mitochondrial fraction of rat liver, Voprosy meditsinskoi khimii, 1976, vol: 22(2), 245-254.
References
 1985(Vol:31)
 1984(Vol:30)
 1983(Vol:29)
 1982(Vol:28)
 1981(Vol:27)
 1980(Vol:26)
 1979(Vol:25)
 1978(Vol:24)
 1977(Vol:23)
 1976(Vol:22)