Voprosy meditsinskoi khimii (ISSN 0042-8809)

Role of intracellular proteinases and glycosidases in the degradation of the 'large glycoprotein' responsible for the neuraminidase and hemagglutinating activity of the Newcastle disease virus

   
Tsvetkova I.V., Chemm L.V.
PubMed Id: 1025889
Year: 1976 vol: 22  issue:2  pages: 266-269
Abstract: It was shown that the decrease in neuraminidase and hemagglutinin activities in Newcastle disease virus (NDV) infected cells, which was revealed in conditions of disturbed protein synthesis, could be significantly diminished by addition of an inhibitor or trypsin-like proteinases tosyl-lysil-chloromethyl keton. The same effect was caused by D-galactonolactone--inhibitor of some glycosidases. These data suggested that the action of intracellular proteinases and glycosidases are the cause of degradation of 'large glycoprotein', responsible for neuraminidase and hemagglutinin activities in NDV-infected cells.
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Reference: Tsvetkova I.V., Chemm L.V., Role of intracellular proteinases and glycosidases in the degradation of the 'large glycoprotein' responsible for the neuraminidase and hemagglutinating activity of the Newcastle disease virus, Voprosy meditsinskoi khimii, 1976, vol: 22(2), 266-269.
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