Voprosy meditsinskoi khimii (ISSN 0042-8809)

Role of salivary kallikrein in the pathogenesis of periodontosis

   
Barabash R.D., Levitskiĭ A.P., Loginova N.K., Yovchuk S.V., Genesina T.I.
PubMed Id: 1088326
Year: 1976 vol: 22  issue:3  pages: 318-325
Abstract: In patients with parodontosis the distinct increase in salivary kallikrein secretion was found. In Wistar rats the intensity of age atrophy of alveoli dentalis correlated with BAEE-esterase activity of mixed saliva. Desalivation considerably decreased the rate of age atrophy of parodontosis in rats. Salivary kallikrein, penetrating in active form into parodontal tissues, caused the pronounced vasodilation in dogs and golden hamsters. By means of kallikrein preparations an intensive inflammatory-dystrophical process was reproduced in parodontal tissues of Wistar rats. The local treatment of patients with parodontosis by kallikrein inhibitors was found to be especially effective.
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Reference: Barabash R.D., Levitskiĭ A.P., Loginova N.K., Yovchuk S.V., Genesina T.I., Role of salivary kallikrein in the pathogenesis of periodontosis, Voprosy meditsinskoi khimii, 1976, vol: 22(3), 318-325.
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