Voprosy meditsinskoi khimii (ISSN 0042-8809)

Changes in phosphorus-calcium metabolism in experimental renal insufficiency and after administration of dihydrotachysterol and thyrocalcitonin

   
Migunova N.A., Ermolenko V.M., Nikiforova N.V., Malinina N.V., Blazheevich N.V.
PubMed Id: 1030898
Year: 1976 vol: 22  issue:3  pages: 400-406
Abstract: Development of experimental chronic renal insufficiency in rats was accompanied by an increase in concentration of residual nitrogen and phosphorus in blood and also by a decrease in intestinal absorption of Ca2+, however, no hypocalcemia was observed and the alkaline phosphatase activity was unaltered in blood serum. At the same time the renal insufficiency caused in some animals metastatic calcification of aorta and kidney, which was manifested by increased calcium concentration in these tissues. Administration of dihydrotachysterol increased the active transport of Ca2+ in rat intestine at the later steps of the impairment and led to development of moderate hypercalcemia and particularly to an increase in the degree of calcinosis of aorta and kidney. Administration of thyrocalcitonine did not prevent the hypercalcemia and calcinosis of internal tissues.
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Reference: Migunova N.A., Ermolenko V.M., Nikiforova N.V., Malinina N.V., Blazheevich N.V., Changes in phosphorus-calcium metabolism in experimental renal insufficiency and after administration of dihydrotachysterol and thyrocalcitonin, Voprosy meditsinskoi khimii, 1976, vol: 22(3), 400-406.
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