Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effect of psychotropic preparations on the activity of Ca- and Mg-dependent ATPase of the sarcoplasmic reticulum

   
Tat'ianenko L.V., Lavretskaia Z.F., Raikhman L.M., Moshkovskii Iu.S., Lebedeva O.I.
PubMed Id: 16400
Year: 1976 vol: 22  issue:3  pages: 406-410
Abstract: In sarcoplasmic reticulum of rabbit skeletal muscles the activity of Ca2+, Mg2+- dependent ATPase was distinctly inhibited under effect of neuroleptic drugs - derivatives of phenothiazine and butyrophenone. The effect of tricyclic antidepressants was less pronounced. Tranquilizers (derivatives of 1,4-benzodiazepine) inhibited the enzyme, but trioxazin was only slightly active. High concentrations of lithium salts and of psychostimulants caffeine and corasole were found to stimulate the Ca2+, Mg2+-ATPase activity; low concentrations of the substances slightly inhibited the enzyme. The blocking effect of psychotropic drugs was more distinct, if the enzyme preparations were previously treated with ATP.
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Reference: Tat'ianenko L.V., Lavretskaia Z.F., Raikhman L.M., Moshkovskii Iu.S., Lebedeva O.I., Effect of psychotropic preparations on the activity of Ca- and Mg-dependent ATPase of the sarcoplasmic reticulum, Voprosy meditsinskoi khimii, 1976, vol: 22(3), 406-410.
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