Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effect of Central Asian cobra (Naja naja oxiana) venom on the biosynthesis of nucleic acids and protein in animal cells

   
Turakulov I.Kh., Khalikov S.K., Rakhimov M.M., Sorokin V.M.
PubMed Id: 1027229
Year: 1976 vol: 22  issue:4  pages: 462-465
Abstract: Cobra poison at a dose of 4 microng/kg of body weight intensified the 3H-thimidine incorporation into DNA of mice liver tissue; 20-40 microng/kg of the poison inhibited the incorporation. Single intraperitoneal administration of high doses of cobra poison (50-150 microng/kg) decreased the incorporation of 14C-thimidine into DNA 1.2-1.9-fold. Little doses of the poison increased the incorporation of 14C-hydrolysate of Chlorella protein into proteins of liver cells and the high doses inhibited this process. Microdoses of cobra poison caused a distinct increase in weight of experimental mice.
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Reference: Turakulov I.Kh., Khalikov S.K., Rakhimov M.M., Sorokin V.M., Effect of Central Asian cobra (Naja naja oxiana) venom on the biosynthesis of nucleic acids and protein in animal cells, Voprosy meditsinskoi khimii, 1976, vol: 22(4), 462-465.
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