Voprosy meditsinskoi khimii (ISSN 0042-8809)

Ubiquinone and cholesterol content and biosynthesis in the hypertrophied kidney of white rats following unilateral nephrectomy

   
Fedurov V.V.
PubMed Id: 1027231
Year: 1976 vol: 22  issue:4  pages: 472-475
Abstract: Within 3 days after dextralateral nephrectomy the weight of left kidney was increased by 24.0%, yield of mitochondrial protein--on the average, by 38.0%, the succinate dehydrogenase activity--by 40.0%. Content of ubiquinone was essentially unaltered in kidney within 3 days after the nephrectomy; in mitochondria concentration of the coenzyme (calculated per mg of protein) was decreased at the 3-rd day after the operation. Biosynthesis of ubiquinone was increased at the 2-nd day after the nephrectomy in slices of hypertrophied kidney; it was studied by incorporation of 1-14C-acetate. Biosynthesis of cholesterol was increased at the same time, especially within the 1-st and 2-nd days after the operation. Content of cholesterol was increased in hypertrophied kidney within the 3-rd day after the operation.
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Reference: Fedurov V.V., Ubiquinone and cholesterol content and biosynthesis in the hypertrophied kidney of white rats following unilateral nephrectomy, Voprosy meditsinskoi khimii, 1976, vol: 22(4), 472-475.
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