Voprosy meditsinskoi khimii (ISSN 0042-8809)

Study of the role of endogenous 3',5'-cyclic AMP in the radioresistance of the cell

   
Shivotova N.I., Filippovich I.V., Romantsev E.F.
PubMed Id: 194414
Year: 1976 vol: 22  issue:4  pages: 533-538
Abstract: A survival period of irradiated rat thymocytes was studied after administration of several possible modifiers of intracellular 3',5'-cyclo AMP. Theophylline, which inhibits 3',5'-cyclo AMP phosphodiesterase, adrenaline, ATP and adenosine possessed a radioprotective effect if they were added before the irradiation or just immediately after it. Imidazole activated 3',5'-cyclo AMP phosphodiesterase and, being added within the above-mentioned periods, it shortened the survival period at the irradiated cells. When theophylline and imidazole were added within 30 min after the irradiation, their effect was completely altered: imidazole increased but theophylline decreased the survival period of the irradiated cells. 3',5'-cyclo AMP and N6-2'-0-dibutyryl-3',5'-cyclo AMP did not affect the viability of thymocytes after the irradiation.
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Reference: Shivotova N.I., Filippovich I.V., Romantsev E.F., Study of the role of endogenous 3',5'-cyclic AMP in the radioresistance of the cell, Voprosy meditsinskoi khimii, 1976, vol: 22(4), 533-538.
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