Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effect of kynurenine and its metabolites on the concentration of 11-hydroxycorticosteroids in rat plasma

   
Lapin I.P., Prakh'e I.B., Khaunina R.A.
PubMed Id: 1014469
Year: 1976 vol: 22  issue:5  pages: 600-602
Abstract: Injections of kynurenine (10 and 25 mg/kg, i.p.) and nicotinic acid (50 mg/kg i.p.) produced a marked increase in concentration of 11-hydroxycorticosteroids (11-HCS) in rat blood plasma. Effect of nicotinic acid was not prevented by dexamethazone (0.6 mg/kg). Subtreshold dose of nicotinic acid (10 mg/kg) enhanced a rise in 11-HCS produced by swimming stress. 3-hydroxykynurenine, 3-hydroxyanthranilic, antranilic picolinic and quinolinic acids (10-50 mg/kg) did not change the concentration of 11-HCS. It is suggested that some of the biochemical and pharmacological effects of injected kynurenine can be mediated through the rise of 11-HCS in blood.
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Reference: Lapin I.P., Prakh'e I.B., Khaunina R.A., Effect of kynurenine and its metabolites on the concentration of 11-hydroxycorticosteroids in rat plasma, Voprosy meditsinskoi khimii, 1976, vol: 22(5), 600-602.
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