Voprosy meditsinskoi khimii (ISSN 0042-8809)

Relationship between the structural state of chromatin and the biosynthesis of rapidly labeling nuclear RNA in the thymuses of rats subjected to total x-irradiation

   
Val'kovich A.A., Khanson K.P.
PubMed Id: 1014474
Year: 1976 vol: 22  issue:5  pages: 643-648
Abstract: Accumulation of polydeoxyribonucleotides (PDN) was studied in thymus of rats, subjected to total body X-ray irradiation at doses 400 and 800 rad. The content of PDN correlated with the time of treatment; its low-polymer components prevailed after irradiation with 800 rad. Protein/DNA ratio was decreased in DNP within 30 min after the irradiation and it returned to the initial level within 4 hrs. Capacity of DNP to make a complex with actinomycin D was inhibited within 30 min; however it exceeded the control level within 4 hrs after irradiation. Biosynthesis of nuclear RNA, estimated by incorporation of 14C-uridine, was distinctly decreased within the whole experimental period.
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Reference: Val'kovich A.A., Khanson K.P., Relationship between the structural state of chromatin and the biosynthesis of rapidly labeling nuclear RNA in the thymuses of rats subjected to total x-irradiation, Voprosy meditsinskoi khimii, 1976, vol: 22(5), 643-648.
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