Voprosy meditsinskoi khimii (ISSN 0042-8809)

Regulation of peroxidation of mitochondrial membrane lipids initiated by Fe2+ ions by antoxidants of the 1,4-dihydropyridine series in experiments in vitro

   
Dubur G.Ya., Velena A.Kh., Gukasov V.M., Vladimirov I.A.
PubMed Id: 1014479
Year: 1976 vol: 22  issue:5  pages: 665-672
Abstract: Effect of antioxidants on the rate of free radical peroxidation was studied in mitochondria in presence of Fe2+. For this purpose derivatives of 1,4-dihydroxypyridine, their heteroaromatic analogues, NAD-H+ and butyl hydroxytoluene (35 substances) were tested in the system by chemoluminescence. Several 1,4-dihydroxypyridine derivatives were found to be effective reagents in the system and could be compared by the activity with the recognized synthetic antioxidant butyl hydroxytoluene.
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Reference: Dubur G.Ya., Velena A.Kh., Gukasov V.M., Vladimirov I.A., Regulation of peroxidation of mitochondrial membrane lipids initiated by Fe2+ ions by antoxidants of the 1,4-dihydropyridine series in experiments in vitro, Voprosy meditsinskoi khimii, 1976, vol: 22(5), 665-672.
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