Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effect of cortisol on the state of adenyl cyclase system in rabbits

   
Speranskaia N.V., Ozerova I.N., Chernysheva N.P., Gerasimova E.N.
PubMed Id: 194416
Year: 1976 vol: 22  issue:6  pages: 746-749
Abstract: Content of 3',5'-cycloAMP was estimated in rabbit blood plasma and urine; activities of adenylcyclase and phosphodiesterase were determined in liver tissue, adipose tissue and adrenal glands within 5, 24 and 48 hrs after hydrocortisone administration. Concentration of 3',5'-cycloAMP was found to be increased 4-6-fold in plasma and urine after the hormone administration. Cortisol was shown to increase also the activity of adenylcyclase and phosphodiesterase in liver tissue within 5 hrs and in adipose tissue--within 24 hrs and 48 hrs after the administration. In adrenal glands hydrocortisone caused an inhibitory effect on the adenylcyclase activity at early steps of the experiment.
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Reference: Speranskaia N.V., Ozerova I.N., Chernysheva N.P., Gerasimova E.N., Effect of cortisol on the state of adenyl cyclase system in rabbits, Voprosy meditsinskoi khimii, 1976, vol: 22(6), 746-749.
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