Voprosy meditsinskoi khimii (ISSN 0042-8809)

Antivitamin activity of thiaminase from freshwater bicuspid molluscs after parenteral administration of the enzyme to albino mice

   
Puzach S.S., Ostrovskiĭ I.M.
PubMed Id: 1027249
Year: 1976 vol: 22  issue:6  pages: 769-773
Abstract: Thiaminase from bicuspid mollusc, after a single administration into mice (25 or 50 un, subcutaneously), caused a decrease in the activity of transketolase and alpha-ketoglutaric acid dehydrogenase in the animal tissues within 3 hrs. The maximal antivitaminous effect of thiaminase was manifested within 2-5 days and slightly decreased within 7 days (at a dose of 25 un). Amount of thiamin was decreased in mice liver tissue from 6.54+/-0.36 mcg/g to 4.84+/-0.23 mcg/g within the second day after the thiaminase administration. Transketolase and alpha-ketoglutarate dehydrogenase from liver and kidney were more sensitive to the antivitaminous effect of thiaminase. General condition of the animals was not altered by parenteral administration of thiaminase during a week. Thiaminase may be recommended for modelling of thiamin deficiency in animals maintained at conventional diets.
Download PDF:
Reference: Puzach S.S., Ostrovskiĭ I.M., Antivitamin activity of thiaminase from freshwater bicuspid molluscs after parenteral administration of the enzyme to albino mice, Voprosy meditsinskoi khimii, 1976, vol: 22(6), 769-773.
References
 1985(Vol:31)
 1984(Vol:30)
 1983(Vol:29)
 1982(Vol:28)
 1981(Vol:27)
 1980(Vol:26)
 1979(Vol:25)
 1978(Vol:24)
 1977(Vol:23)
 1976(Vol:22)