Voprosy meditsinskoi khimii (ISSN 0042-8809)

Role of salivary ribonuclease in pathogenesis of periodontosis

   
Barabash R.D., Levitskiĭ A.P., Genesina T.I., Konovets V.M.
PubMed Id: 17223
Year: 1976 vol: 22  issue:6  pages: 784-791
Abstract: In patients with periodontal disease a distinct increase in secretion of salivary acidic and alkaline RNAases was found. The RNAases activity in mixed saliva correlated with the intensity of degradation of periodontal tissues during loss of alveolar layer in aged Wistar rats and the spontaneous periodontal disease in cats. In experiments with golden hamsters salivary RNAase was found to penetrate through mucosa in active form. The purified salivary RNAase inhibited the protein biosynthesis in rabbit gingiva. Intensive atrophic alterations were produced in periodontal tissues of Wistar rats by means of purified salivary RNAase.
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Reference: Barabash R.D., Levitskiĭ A.P., Genesina T.I., Konovets V.M., Role of salivary ribonuclease in pathogenesis of periodontosis, Voprosy meditsinskoi khimii, 1976, vol: 22(6), 784-791.
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