Voprosy meditsinskoi khimii (ISSN 0042-8809)

Nature of changes in the activity of certain enzymes of energy metabolism in the liver after partial sympathectomy

   
Parfenova N.S., Shanygina K.I.
PubMed Id: 1027252
Year: 1976 vol: 22  issue:6  pages: 808-812
Abstract: Partial sympathectomy of rat liver, carried out by bilateral section of celiac nerves, caused a distinct increase in the activity of hexokinase and glucose-6-phosphate dehydrogenase and (less distinctly) of 6-phosphogluconate dehydrogenase and lactate dehydrogenase in liver tissue. The alterations in glucokinase activity were not statistically significant. Noradrenaline disappeared completely from rat liver after the celiac nerves section. Activities of the above-mentioned enzymes were altered to the same degree in sympathectomized liver of adrenalectomized animals. The increase in the hexokinase and glucose-6-phosphate dehydrogenase activity was prevented by administration of actinomycin D immediately after the section of celiac nerves. The data obtained suggest that after section of liver celiac nerves the alterations in the enzymatic activities are determined by the increase of their biosynthesis and occur as a result of impairment of liver sympathetic innervation.
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Reference: Parfenova N.S., Shanygina K.I., Nature of changes in the activity of certain enzymes of energy metabolism in the liver after partial sympathectomy, Voprosy meditsinskoi khimii, 1976, vol: 22(6), 808-812.
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