Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effect of rimantadine on the synthesis of virus-specific RNA in the culture of cells infected with Sindbis virus

   
Dikii V.V., Petkevich A.S., Leont'eva N.A., Galegov G.A.
PubMed Id: 1027258
Year: 1976 vol: 22  issue:6  pages: 844-848
Abstract: Effect of rimanthadine (alpha-methyl-I-adamantane methylamine) on the synthesis of virus specific RNA was studied in culture of cells, infected with Syndbis virus. Rimanthadine inhibits the synthesis of virus specific RNA beginning from the 3-rd hr of infection. A magnitude of inhibition from the 3-rd to the 7-th hrs of infection was practically the same and exceeded 50%. In the presence of rimanthadine "early" RNA was formed (with sedimentation constant of 20-14 S), where radioactivity was lowered as compared with control; formation of more "late" RNA peaks (43 S, 34 S and 26 S) was completely prevented within these periods of infection.
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Reference: Dikii V.V., Petkevich A.S., Leont'eva N.A., Galegov G.A., Effect of rimantadine on the synthesis of virus-specific RNA in the culture of cells infected with Sindbis virus, Voprosy meditsinskoi khimii, 1976, vol: 22(6), 844-848.
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