Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effect of actinomycin D and ethionine on hormonal induction of ribonucleic acid synthesis in the nuclei and cytoplasm of the liver cells of adult male rats

   
Ponomarev V.I.
PubMed Id: 855230
Year: 1977 vol: 23  issue:1  pages: 66-68
Abstract: Ethionine did not affect but actinomycin D inhibited the increase in DNA-like RNA synthesis (precursor of ribosomal RNA in nuclei and rRNA in cytoplasm of liver tissue cells of adult male rats), which was caused by single administration of hydrocortisone or protamine-Zn-insulin and by both hormones. The data obtained suggest that the effect of these hormones on the synthesis of DNA-like RNA was realized at the stage of transcription.
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Reference: Ponomarev V.I., Effect of actinomycin D and ethionine on hormonal induction of ribonucleic acid synthesis in the nuclei and cytoplasm of the liver cells of adult male rats, Voprosy meditsinskoi khimii, 1977, vol: 23(1), 66-68.
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