Voprosy meditsinskoi khimii (ISSN 0042-8809)

Dynamics of incorporation of 35S-thiamine and its phosphorus esters into the liver cells of white rats of different ages

   
Karpov L.M., Rozanov A.Ya.
PubMed Id: 857408
Year: 1977 vol: 23  issue:1  pages: 69-73
Abstract: Metabolites of 35S-thiamin as well as its mono- and diphosphorous esters were administered at a dose of 150 nM/kg intraperitoneally into rats of various age. The total accumulation of thelabel was increased in liver cell fractions in ontogenesis. Dynamics of 35S-thiamin accumulation was shown to have a biphase type and the phosphorous esters--a monophase one within 30-240 min after administration of the label. The major part of thiamin was accumulated in soluble and nuclear fractions of liver cells and the phosphorous esters (especially thiamin diphosphate)--in mitochondrial fraction. In adult rats the highest amount of the labelled preparations was observed in liver mitochondria as compared with other cell fractions. Ageing of animals was accompanied by the increase in metabolism of vitamin B1 in liver cell fractions.
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Reference: Karpov L.M., Rozanov A.Ya., Dynamics of incorporation of 35S-thiamine and its phosphorus esters into the liver cells of white rats of different ages, Voprosy meditsinskoi khimii, 1977, vol: 23(1), 69-73.
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