Voprosy meditsinskoi khimii (ISSN 0042-8809)

Biosynthesis and cellular localization of betal-g-globulin in the human placenta

   
Tatarinov Iu.S., Falaleeva D.M., Kalashnikova V.V., Vasil'ev M.Iu.
PubMed Id: 404761
Year: 1977 vol: 23  issue:1  pages: 88-92
Abstract: Pregnancy-specific beta1-globulin (beta1-GP) described by Tatarinov and Masyukevich, 1970) was shown by means of immunodiffusion in agar gel to be similar to specific pregnancy beta1-glycoprotein of Bohn (1971) as well as to pregnancy associated plasma protein-C of Lin et al (1974). It was found that in immature placenta (6-12 weeks of pregnancy) incorporation of 14S-amino acids into beta1-GP took place. Studies on immunofluorescence showed that beta1-GP was localized in cytoplasma of trophoblastic cells of placenta chorion. Beta1-GP production apparently begins in Langhans cells and proceeds in syncytiotrophoblastic cells, but at lower activity and secretory scale.
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Reference: Tatarinov Iu.S., Falaleeva D.M., Kalashnikova V.V., Vasil'ev M.Iu., Biosynthesis and cellular localization of betal-g-globulin in the human placenta, Voprosy meditsinskoi khimii, 1977, vol: 23(1), 88-92.
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