Voprosy meditsinskoi khimii (ISSN 0042-8809)

Mechanism of inhibition of rat liver microsomal monooxygenases during the development of cholestasis

   
Zakharova N.E., Pospelova L.N., Gromova O.A., Tsyrlov I.B., Liakhovich V.V.
PubMed Id: 883154
Year: 1977 vol: 23  issue:2  pages: 181-185
Abstract: Alterations in the activity of rat liver monoxygenases were studied in dynamics of cholestasis development after ligation of biliary duct and the effects observed were compared to the latter after addition of cholesterol hydroxylated derivatives in vitro. Sodium deoxycholate at concentration 0.06-0.07% was shown to stimulate the alterations in the microsomal monooxygenases activity within fourth day and at concentration 0.09-0.12%--within seventh day of cholestasis.
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Reference: Zakharova N.E., Pospelova L.N., Gromova O.A., Tsyrlov I.B., Liakhovich V.V., Mechanism of inhibition of rat liver microsomal monooxygenases during the development of cholestasis, Voprosy meditsinskoi khimii, 1977, vol: 23(2), 181-185.
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