Voprosy meditsinskoi khimii (ISSN 0042-8809)

Glycoprotein components of the skin under normal conditions and in several types of pathology

   
Dobrotina N.A., Ezhova G.P.
PubMed Id: 883158
Year: 1977 vol: 23  issue:2  pages: 215-219
Abstract: Content of sialic acids was increased 2.9-3.4-fold in soluble fraction of pathologically altered skin (parakeratotoic scales in psoriasis and allergo dermatoses) as compared with a skin of healthy persons. In parakeratotic scales 7-11 zones of PAS (positive glycoproteins) were found by polyacrylamide gel disc electrophoresis; they occurred in skin of healthy persons only in several cases. Hemoglobin-binding activity (haptoglobin) was observed in pathologically altered skin of 64-93% patients with psoriasis; it was not found in healthy persons. The spectrum of haptoglobin fractions in skin correlated with its phenotype in blood.
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Reference: Dobrotina N.A., Ezhova G.P., Glycoprotein components of the skin under normal conditions and in several types of pathology, Voprosy meditsinskoi khimii, 1977, vol: 23(2), 215-219.
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