Voprosy meditsinskoi khimii (ISSN 0042-8809)

Synthesis, physico-chemical and antigenic properties of the conjugated antigens of xanthine- and theophylline proteins

   
Polevaia O.Yu., Danilova N.P., Rubtsova E.R., Kovalev I.E.
PubMed Id: 70110
Year: 1977 vol: 23  issue:2  pages: 232-237
Abstract: Conjugated antigens of xanthine- and theophylline-protein were synthesized by the reaction of diazosalts of 8-aminoxanthine and 8-aminotheophylline with bovine serum albumin. UV-spectra of the synthesized preparations were studied and content of xanthine and theophylline, covalently bound with the substances, was estimated. Immunization of animals with the conjugates was found to cause the occurrence of antibodies in blood serum, which bound specifically various derivatives of purine.
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Reference: Polevaia O.Yu., Danilova N.P., Rubtsova E.R., Kovalev I.E., Synthesis, physico-chemical and antigenic properties of the conjugated antigens of xanthine- and theophylline proteins, Voprosy meditsinskoi khimii, 1977, vol: 23(2), 232-237.
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