Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effects of hydroxythiamine and citrate on several reactions of the pentose phosphate cycle and glycolysis

   
Trebukhina R.V., Ostrovskii Iu.M., Mikhal'tsevich G.N., Borodinskii A.N., Lashak L.K.
PubMed Id: 142370
Year: 1977 vol: 23  issue:2  pages: 266-270
Abstract: Hydroxythiamin was shown to inhibite distinctly phosphofructokinase and phosphohexoisomerase besides a direct antivitaminous effect on transketolase. In this case the regulatory action is likely to be carried out by erythrose-4-phosphate, accumulating in liver tissue. Citrate (administered separately and together with hydroxythiamin) is assumed to influence indirectly the transketolase activity affecting the total regulation of carbohydrate metabolism.
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Reference: Trebukhina R.V., Ostrovskii Iu.M., Mikhal'tsevich G.N., Borodinskii A.N., Lashak L.K., Effects of hydroxythiamine and citrate on several reactions of the pentose phosphate cycle and glycolysis, Voprosy meditsinskoi khimii, 1977, vol: 23(2), 266-270.
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