Voprosy meditsinskoi khimii (ISSN 0042-8809)

Haptoglobin and ceruloplasmin in systemic scleroderma

   
Volkova Z.I., Kainova A.S., Balabanova R.M.
PubMed Id: 888393
Year: 1977 vol: 23  issue:3  pages: 294-297
Abstract: Content of haptoglobin and ceruloplasmin was estimated in blood serum of 23 patients with sclerodermia systematica. A statistically distinct decrease in ceruloplasmin concentration was observed in blood of the patients, whereas content of haptoglobin was markedly increased; this phenomenon reflects a level of the pathological process activity. The proteins are synthesized in various zones of liver lobes: haptoglobin--in the central zone, ceruloplasmin - in the peripheral one. Decrease in content of ceruloplasmin in blood of patients with sclerodermia systematica was due to impairment of hepatocytes, localized in peripheral parts of liver lobes.
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Reference: Volkova Z.I., Kainova A.S., Balabanova R.M., Haptoglobin and ceruloplasmin in systemic scleroderma, Voprosy meditsinskoi khimii, 1977, vol: 23(3), 294-297.
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